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1

Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of dabigatran etexilate, intermediate metabolite and dabigatran in 50μL rat plasma and its application to pharmacokinetic study

Li, Jinyin, Fang, Jing, Zhong, Fanyi, Li, Wenxue, Tang, Yuanjun, Xu, Yungen, Mao, Shilong, Fan, Guorong

Journal:

Journal of Chromatography B

Année:

2014

Langue:

english

Fichier:

PDF, 618 KB

english, 2014

2

Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities

Zhang, Xu, Ba, Qian, Gu, Zhanni, Guo, Diliang, Zhou, Yu, Xu, Yungen, Wang, Hui, Ye, Deju, Liu, Hong

Journal:

Chemistry - A European Journal

Année:

2015

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2015

3

Synthesis of Novel Ligustrazine Derivatives as Na+/H+ Exchange Inhibitors

Mei Ren, Jin Dong, Yungen Xu, Nan Wen, Guoqing Gong

Journal:

Chemistry & Biodiversity

Année:

2010

Langue:

english

Fichier:

PDF, 187 KB

english, 2010

4

[Fe(F 20 TPP)Cl]-Catalyzed Amination with Arylamines and {[Fe(F 20 TPP)(NAr)](PhINAr)} + . Intermediate Assessed by High-Resolution ESI-MS and DFT Calculations

Liu, Yungen, Chen, Guo-Qiang, Tse, Chun-Wai, Guan, Xianguo, Xu, Zheng-Jiang, Huang, Jie-Sheng, Che, Chi-Ming

Journal:

Chemistry – An Asian Journal

Année:

2015

Langue:

english

Fichier:

PDF, 4.66 MB

english, 2015

5

Novel Synthesis of anti-obesity Drug Lorcaserin Hydrochloride

Zhu, Qihua, Wang, Junwei, Bian, Xueguo, Zhang, Lingzhi, Wei, Ping, Xu, Yungen

Journal:

Organic Process Research & Development

Année:

2015

Langue:

english

Fichier:

PDF, 1000 KB

english, 2015

6

Design, Synthesis, and Biological Evaluation of Dabigatran Etexilate Mimics, a Novel Class of Thrombin Inhibitors

Wang, Shaochi, Dai, Peng, Xu, Yungen, Chen, Qiufang, Zhu, Qihua, Gong, Guoqing

Journal:

Archiv der Pharmazie

Année:

2015

Langue:

english

Fichier:

PDF, 743 KB

english, 2015

7

Design, synthesis and biological evaluation of novel 3 H -imidazole [4,5- b ] pyridine derivatives as selective mTOR inhibitors

Zhang, Lingzhi, Bu, Tantan, Bao, Xiaobo, Liang, Tingting, Ge, Yiran, Xu, Yungen, Zhu, Qihua

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 526 KB

english, 2017

8

Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease

Yang, Jian, Zhang, Xueli, Yuan, Peng, Yang, Jing, Xu, Yungen, Grutzendler, Jaime, Shao, Yihan, Moore, Anna, Ran, Chongzhao

Journal:

Proceedings of the National Academy of Sciences

Année:

2017

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2017

9

Recent advances in inhibitors of sirtuin1/2: an update and perspective

Zhou, Ziyan, Ma, Tianfang, Zhu, Qihua, Xu, Yungen, Zha, Xiaoming

Journal:

Future Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 4.12 MB

english, 2018

10

A new fluorescent probe for quick and highly selective detection of hydrogen sulfide and its application in living cells

Ren, Yanshen, Zhang, Lulu, Zhou, Ziyan, Wang, Suilou, Xu, Yungen, Gu, Yueqing, Zha, Xiaoming

Journal:

New Journal of Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.55 MB

english, 2018

11

Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders

Xu, Jinping, Wang, Hongwei, Zhang, Lu, Xu, Ziyun, Li, Tian, Zhou, Zhifeng, Zhou, Zhenhui, Gan, Yungen, Hu, Qingmao

Journal:

Frontiers in Neuroscience

Année:

2018

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2018

12

Iron- and cobalt-catalyzed C(sp 3 )âH bond functionalization reactions and their application in organic synthesis

Liu, Yungen, You, Tingjie, Wang, Hai-Xu, Tang, Zhou, Zhou, Cong-Ying, Che, Chi-Ming

Journal:

Chemical Society Reviews

Année:

2020

Fichier:

PDF, 24.01 MB

2020

13

Stereoselective Synthesis of Multifunctionalized 1,2,4-Triazolidines by a Ruthenium Porphyrin-Catalyzed Three-Component Coupling Reaction

Ming-Zhong Wang, Hai-Wei Xu, Yungen Liu, Man-Kin Wong, Chi-Ming Che

Journal:

Advanced Synthesis & Catalysis

Année:

2006

Langue:

english

Fichier:

PDF, 109 KB

english, 2006

14

An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization

Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang, Hong Liu

Journal:

Advanced Synthesis & Catalysis

Année:

2011

Langue:

english

Fichier:

PDF, 290 KB

english, 2011

15

Synthesis and Na+/H+ Exchanger-1 Inhibitory Activity of Substituted (Quinolinecarbonyl)guanidine Derivatives

Dan Mao, Yungen Xu, Xiaoping Hu, Guomin Zhang, Jin Dong, Guoqing Gong

Journal:

Chemistry & Biodiversity

Année:

2009

Langue:

english

Fichier:

PDF, 196 KB

english, 2009

16

ChemInform Abstract: Synthesis of N-Heteroaryl Aminosaccharide Derivatives as Fibroblast Growth Factor 2 Signaling Modulators.

Jin Dong, Shuowei Yao, Xiaodong Zhou, Lijuan Zhang, Yungen Xu

Journal:

Année:

2011

Fichier:

PDF, 27 KB

2011

17

ChemInform Abstract: Silver-Catalyzed Intramolecular Hydroamination of Alkynes in Aqueous Media: Efficient and Regioselective Synthesis for Fused Benzimidazoles.

Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang, Hong Liu

Journal:

Année:

2011

Fichier:

PDF, 42 KB

2011

18

ChemInform Abstract: Iron-Catalyzed Nitrene Insertion Reaction for Facile Construction of Amide Compounds.

Guo-Qiang Chen, Zhen-Jiang Xu, Yungen Liu, Cong-Ying Zhou, Chi-Ming Che

Journal:

Année:

2011

Fichier:

PDF, 30 KB

2011

19

ChemInform Abstract: An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization.

Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang, Hong Liu

Journal:

Année:

2011

Fichier:

PDF, 34 KB

2011

20

ChemInform Abstract: An Improved Synthesis of Substituted Indan-1-carboxylic Acid.

Zongjie Gan, Di Zhang, Zhe Cao, Yungen Xu

Journal:

Année:

2011

Fichier:

PDF, 35 KB

2011

21

Palladium-Catalyzed Tandem Reactions of β-(2-Bromophenyl)-α,β-Unsaturated Carbonyl Compounds with 2-Hydroxyphenylboronic Acid: A New Route to Benzo[c]chromenes

Qihua Zhu, Xuyan Wang, Yungen Xu

Journal:

European Journal of Organic Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 148 KB

english, 2012

22

ChemInform Abstract: Palladium-Catalyzed Tandem Reactions of β-(2-Bromophenyl)-α,β-Unsaturated Carbonyl Compounds with 2-Hydroxyphenylboronic Acid: A New Route to Benzo[c]chromenes.

Qihua Zhu, Xuyan Wang, Yungen Xu

Journal:

Année:

2012

Fichier:

PDF, 27 KB

2012

23

ChemInform Abstract: Convenient Chlorination of Some Special Aromatic Compounds Using N-Chlorosuccinimide.

Zongjie Gan, Bin Hu, Qiao Song, Yungen Xu

Journal:

Année:

2012

Fichier:

PDF, 27 KB

2012

24

Synthesis and Bioactivity of Substituted Benzoylguanidine Derivatives as Potent Na+/H+ Exchanger Inhibitors

Ning Jin, Yun Yang, Wenting Xu, Xiaozhi Yang, Guoqing Gong, Yungen Xu

Journal:

Chinese Journal of Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 418 KB

english, 2012

25

The cardioprotective effect of TG-6, a newly synthesized compound, on ischemia-reperfusion injury in rats

Yi Zhou, Guoqing Gong, Wenhui Yang, Yin Wang, Jing Xu, Yungen Xu

Journal:

European Journal of Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2012

26

Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors

Zhu, Qihua, Wang, Xuyan, Chu, Zhaoxing, He, Guangwei, Dong, Guangping, Xu, Yungen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 703 KB

english, 2013

27

Scale-Up Synthesis of Antidepressant Drug Vilazodone

Hu, Bin, Song, Qiao, Xu, Yungen

Journal:

Organic Process Research & Development

Année:

2012

Langue:

english

Fichier:

PDF, 355 KB

english, 2012

28

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor

Zhang, Xu, Peng, Ting, Ji, Xun, Li, Jian, Tong, Linjiang, Li, Zeng, Yang, Wei, Xu, Yungen, Li, Mengyuan, Ding, Jian, Jiang, Hualiang, Xie, Hua, Liu, Hong

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 3.16 MB

english, 2013

29

Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility

Yang, Yun, Wang, Xinhui, Zhu, Qihua, Gong, Guoqing, Luo, Danmeng, Jiang, Aidou, Yang, Liyan, Xu, Yungen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 804 KB

english, 2014

30

Synthesis and anti-angiogenetic activity evaluation of N-(3-aryl acryloyl)aminosaccharide derivatives

Liu, Kun, Yao, Shuowei, Lou, Yinghan, Xu, Yungen

Journal:

Carbohydrate Research

Année:

2013

Langue:

english

Fichier:

PDF, 945 KB

english, 2013

31

p -Toluenesulfonohydrazide as Highly Efficient Initiator for Direct C–H Arylation of Unactivated Arenes

Song, Qiao, Zhang, Dongmei, Zhu, Qihua, Xu, Yungen

Journal:

Organic Letters

Année:

2014

Langue:

english

Fichier:

PDF, 372 KB

english, 2014

32

[Fe III (TF 4 DMAP)OTf] catalysed anti-Markovnikov oxidation of terminal aryl alkenes to aldehydes and transformation of methyl aryl tertiary amines to formamides with H 2 O 2 as a terminal oxidant

Du, Yi-Dan, Tse, Chun-Wai, Xu, Zhen-Jiang, Liu, Yungen, Che, Chi-Ming

Journal:

Chemical Communications

Année:

2014

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2014

33

Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking

Zhou, Chen, Kang, Di, Xu, Yungen, Zhang, Luyong, Zha, Xiaoming

Journal:

Chemical Biology & Drug Design

Année:

2015

Langue:

english

Fichier:

PDF, 905 KB

english, 2015

34

Identification of new non-steroidal TGR5 agonists using virtual screening with combined pharmacophore models

Zhou, Chen, Zou, Fangxia, Xu, Yungen, Zhang, Luyong, Zha, Xiaoming

Journal:

Medicinal Chemistry Research

Année:

2015

Langue:

english

Fichier:

PDF, 1.75 MB

english, 2015

35

Convenient Chlorination of Some Special Aromatic Compounds Using N-Chlorosuccinimide

Gan, Zongjie, Hu, Bin, Song, Qiao, Xu, Yungen

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 111 KB

english, 2012

36

An improved synthesis of substituted indan-1-carboxylic acid

Gan, Zongjie, Zhang, Di, Cao, Zhe, Xu, Yungen

Journal:

Journal of Chemical Research

Année:

2011

Langue:

english

Fichier:

PDF, 76 KB

english, 2011

37

Iron-Catalyzed Nitrene Insertion Reaction for Facile Construction of Amide Compounds

Chen, Guo-Qiang, Xu, Zhen-Jiang, Liu, Yungen, Zhou, Cong-Ying, Che, Chi-Ming

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 155 KB

english, 2011

38

Efficient Palladium-Catalyzed C–H Fluorination of C(sp3)–H Bonds: Synthesis of β-Fluorinated Carboxylic Acids

Zhu, Qihua, Ji, Dezhong, Liang, Tingting, Wang, Xueyan, Xu, Yungen

Journal:

Organic Letters

Année:

2015

Langue:

english

Fichier:

PDF, 679 KB

english, 2015

39

Synthesis and biological evaluation of novel laropiprant derivatives as potential anti-allergic agents

Zhou, Haiping, Zhu, Qihua, Gan, Zongjie, Dong, Guangping, Xu, Yungen

Journal:

Medicinal Chemistry Research

Année:

2015

Langue:

english

Fichier:

PDF, 578 KB

english, 2015

40

Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer

Zhu, Qihua, Wang, Xueyan, Hu, Yan, He, Xiaorong, Gong, Guoqing, Xu, Yungen

Journal:

Bioorganic & Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 729 KB

english, 2015

41

Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors

Chen, Dongxing, Wang, Shaochi, Diao, Xiaojuan, Zhu, Qihua, Shen, Huiliang, Han, Xueqing, Wang, Yiwei, Gong, Guoqing, Xu, Yungen

Journal:

Bioorganic & Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 3.63 MB

english, 2015

42

Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

Zha, Xiaoming, Lamba, Doriano, Zhang, Lili, Lou, Yinghan, Xu, Changxu, Kang, Di, Chen, Li, Xu, Yungen, Zhang, Luyong, De Simone, Angela, Samez, Sarah, Pesaresi, Alessandro, Stojan, Jure, Lopez, Manuel

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 3.16 MB

english, 2016

43

Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists

Guo, Ting, Gan, Zongjie, Chen, Jie, Wang, Dechuan, He, Ling, Song, Qiao, Xu, Yungen

Journal:

Bioorganic & Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 853 KB

english, 2016

44

ChemInform Abstract: [Fe III (TF 4 DMAP)OTf] Catalyzed anti-Markovnikov Oxidation of Terminal Aryl Alkenes to Aldehydes and Transformation of Methyl Aryl Tertiary Amines to Formamides with H 2 O 2 as a Terminal Oxidant.

Du, Yi-Dan, Tse, Chun-Wai, Xu, Zhen-Jiang, Liu, Yungen, Che, Chi-Ming

Journal:

Année:

2015

Fichier:

PDF, 23 KB

2015

45

ChemInform Abstract: p-Toluenesulfonohydrazide as Highly Efficient Initiator for Direct C-H Arylation of Unactivated Arenes.

Song, Qiao, Zhang, Dongmei, Zhu, Qihua, Xu, Yungen

Journal:

Année:

2015

Fichier:

PDF, 23 KB

2015

46

ChemInform Abstract: Efficient Palladium-Catalyzed C-H Fluorination of C(sp3)-H Bonds: Synthesis of β-Fluorinated Carboxylic Acids.

Zhu, Qihua, Ji, Dezhong, Liang, Tingting, Wang, Xueyan, Xu, Yungen

Journal:

Année:

2015

Fichier:

PDF, 28 KB

2015

47

ChemInform Abstract: Synthesis of 6-Substituted Phenanthridine Derivatives by Palladium-Catalyzed Domino Suzuki-Miyaura/Aza-Michael Reactions.

Bao, Xiaobo, Yao, Wei, Zhu, Qihua, Xu, Yungen

Journal:

Année:

2015

Fichier:

PDF, 20 KB

2015

48

Palladium-catalyzed Synthesis of Novel O-Heterocycles by Domino Suzuki Coupling-Michael Addition Reaction

Zhu, Qihua, Nie, Feng, Feng, Jingjie, Li, Yuyan, Wang, Xuyan, Xu, Yungen

Journal:

Journal of Heterocyclic Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2016

49

Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors

Wang, Junwei, Wang, Xuyan, Li, Hui, Ji, Dezhong, Li, Yuyan, Xu, Yungen, Zhu, Qihua

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 3.27 MB

english, 2016

50

Highly Enantioselective Iron-Catalyzed cis -Dihydroxylation of Alkenes with Hydrogen Peroxide Oxidant via an Fe III -OOH Reactive Intermediate

Zang, Chao, Liu, Yungen, Xu, Zhen-Jiang, Tse, Chun-Wai, Guan, Xiangguo, Wei, Jinhu, Huang, Jie-Sheng, Che, Chi-Ming

Journal:

Angewandte Chemie International Edition

Année:

2016

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2016